Are Polynucleotides really made from salmon sperm?

Polynucleotides treatment, Kent and London

Polynucleotides are rapidly becoming one of the most talked-about treatments in aesthetic medicine, praised for their ability to rejuvenate the skin, improve elasticity, and boost collagen production. However, one of the most intriguing—and often misunderstood—questions about this treatment is: Are polynucleotides really made from salmon sperm? While it might sound surprising, the answer is both yes and no. Let’s break down what polynucleotides are, how they work, what they’re made from, and why not all polynucleotide products are created equal.

What are polynucleotides?

Polynucleotides are powerful skin-rejuvenating molecules derived from DNA fragments. These molecules act as biostimulators, meaning they trigger the body’s natural repair and regeneration processes. Rather than simply filling lines or adding volume like traditional dermal fillers, polynucleotides work at a cellular level to improve skin quality, increase hydration, and stimulate fibroblast activity, which enhances collagen and elastin production.

The treatment is particularly effective for improving skin texture, reducing fine lines, strengthening delicate or damaged skin, and even helping with conditions like acne scarring and rosacea. Polynucleotides have also been used in regenerative medicine for wound healing, showing their incredible ability to repair and restore skin health.

How do polynucleotides work? 

When injected into the skin, polynucleotides initiate a process known as bio-remodelling. They provide essential building blocks for skin regeneration while also acting as a powerful anti-inflammatory agent. This makes them especially beneficial for individuals with sensitive or ageing skin, as they help repair damaged tissue while boosting hydration and elasticity.

The polynucleotides stimulate fibroblasts – cells responsible for producing collagen and elastin – encouraging long-term structural improvements in the skin. Over time, this leads to firmer, more youthful-looking skin with enhanced resilience and radiance. Unlike hyaluronic acid fillers, which deliver instant volume, polynucleotides work gradually, improving skin quality over weeks to months for a natural, long-lasting effect.

What are polynucleotides made from?

This is where things get interesting. Most polynucleotide-based treatments are derived from purified DNA extracted from fish, usually salmon or trout. The DNA is carefully processed and refined to ensure it is biocompatible, meaning it works harmoniously with the body without triggering an immune response.

The reason salmon DNA is commonly used is due to its structural similarity to human DNA. It is highly stable, rich in nucleotides, and provides an ideal foundation for skin regeneration. However, while the original source of these polynucleotides is fish-derived, the treatment does not contain sperm cells or genetic material in the way some myths suggest. The material used is meticulously purified, removing any proteins or contaminants, leaving behind only the beneficial nucleotides that stimulate skin repair.

Why not all polynucleotide products are the same

Just like with any aesthetic treatment, not all polynucleotide products are created equal. Different brands and formulations vary in terms of purity, molecular weight, and processing techniques, all of which can influence their effectiveness. High-quality polynucleotide treatments undergo extensive purification to ensure they are free from unwanted proteins and allergens, making them safer and more effective.

Another key difference is the molecular structure. Some polynucleotides are designed to work more superficially, providing hydration and antioxidant benefits, while others penetrate deeper to stimulate fibroblasts and trigger long-term collagen production. This is why it’s crucial to choose a treatment that is suited to your specific skin concerns and administered by an experienced practitioner who understands the nuances of different formulations.

Product licensing is another concern, with several products on the UK market not licensed for injection but only for topical administration.

Yes, polynucleotides are derived from fish DNA, but no, they are not simply “salmon sperm.” These treatments represent a cutting-edge advancement in regenerative aesthetics, offering powerful skin-rejuvenating benefits without significant risks. By stimulating the body’s natural repair mechanisms, polynucleotides can dramatically improve skin quality, hydration, and elasticity, making them a fantastic option for those looking to enhance their complexion in a natural and long-lasting way.

However, as with any advanced treatment, the quality of the product and the expertise of the practitioner matter. If you’re considering polynucleotide injections, make sure you’re receiving a high-quality formulation tailored to your skin’s needs. When done correctly, polynucleotides can be one of the most effective and scientifically backed ways to rejuvenate and strengthen the skin from within.

If you’d like to learn more about the options, click here to enquire or to book a consultation with an Illuminate Skin Clinic, Kent or London expert.